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The underlying mechanism is likely through secretion of pro-inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-8 (IL-8) which activate hypothalamic-pituitary-adrenal (HPA) and hypothalamic-autonomic nervous system axes, trigger the release of corticotrophin releasing factor (CRF), adrenocorticotropic hormone and cortisol, which consequently affect gut homeostasis (Qin et al., 2014)

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Involvement of the nuclear factor-B pathway in the pathogenesis of endometriosis [J]